| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Proteoglycan 4 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRG4 |
| Gene ID: |
10216 |
| Uniprot ID: |
PRG4_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Lubricin/MSF at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human Lubricin/MSF |
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans. The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage. Proteolytically cleaved by cathepsin CTSG. |
| Function | Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. |
| Protein Name | Proteoglycan 4LubricinMegakaryocyte-Stimulating FactorSuperficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Proteoglycan 4 antibodyAnti-Lubricin antibodyAnti-Megakaryocyte-Stimulating Factor antibodyAnti-Superficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part antibodyAnti-PRG4 antibodyAnti-MSF antibodyAnti-SZP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
