| Tissue Specificity | Detected in plasma and urine (at protein level). Detected in placenta (at protein level). High levels of the proform in placenta and pregnancy serum.in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Post Translational Modifications | Nitrated. |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Protein Name | Bone Marrow ProteoglycanBmpgProteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic ProteinEmbpMbpPregnancy-Associated Major Basic Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Bone Marrow Proteoglycan: SecretedThe Proform Is SecretedEosinophil Granule Major Basic Protein: Cytoplasmic VesicleSecretory VesicleThe Mature Protein Is Found In The Matrix Of The Eosinophil's Large Specific Granule (Crystalloid Core) |
| Alternative Antibody Names | Anti-Bone Marrow Proteoglycan antibodyAnti-Bmpg antibodyAnti-Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein antibodyAnti-Embp antibodyAnti-Mbp antibodyAnti-Pregnancy-Associated Major Basic Protein antibodyAnti-PRG2 antibodyAnti-MBP antibody |
Information sourced from Uniprot.org
