| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Bone Marrow Proteoglycan (17-222) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRG2 |
| Gene ID: |
5553 |
| Uniprot ID: |
PRG2_HUMAN |
| Immunogen Region: |
17-222 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 17-222 of human PRG2 (NP_002719.3). |
| Immunogen Sequence: |
LHLRSETSTFETPLGAKTLP EDEETPEQEMEETPCRELEE EEEWGSGSEDASKKDGAVES ISVPDMVDKNLTCPEEEDTV KVVGIPGCQTCRYLLVRSLQ TFSQAWFTCRRCYRGNLVSI HNFNINYRIQCSVSALNQGQ VWIGGRITGSGRCRRFQWVD GSRWNFAYWAAHQPWSRGGH CVALCTRGGHWRRAHCLRRL PFICSY |
| Tissue Specificity | Detected in plasma and urine (at protein level). Detected in placenta (at protein level). High levels of the proform in placenta and pregnancy serum.in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Post Translational Modifications | Nitrated. |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Protein Name | Bone Marrow ProteoglycanBmpgProteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic ProteinEmbpMbpPregnancy-Associated Major Basic Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Bone Marrow Proteoglycan: SecretedThe Proform Is SecretedEosinophil Granule Major Basic Protein: Cytoplasmic VesicleSecretory VesicleThe Mature Protein Is Found In The Matrix Of The Eosinophil's Large Specific Granule (Crystalloid Core) |
| Alternative Antibody Names | Anti-Bone Marrow Proteoglycan antibodyAnti-Bmpg antibodyAnti-Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein antibodyAnti-Embp antibodyAnti-Mbp antibodyAnti-Pregnancy-Associated Major Basic Protein antibodyAnti-PRG2 antibodyAnti-MBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
