| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRG2 |
| Gene ID: | 5553 |
| Uniprot ID: | PRG2_HUMAN |
| Immunogen Region: | 17-222 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-222 of human PRG2 (NP_002719.3). |
| Immunogen Sequence: | LHLRSETSTFETPLGAKTLP EDEETPEQEMEETPCRELEE EEEWGSGSEDASKKDGAVES ISVPDMVDKNLTCPEEEDTV KVVGIPGCQTCRYLLVRSLQ TFSQAWFTCRRCYRGNLVSI HNFNINYRIQCSVSALNQGQ VWIGGRITGSGRCRRFQWVD GSRWNFAYWAAHQPWSRGGH CVALCTRGGHWRRAHCLRRL PFICSY |
| Tissue Specificity | Detected in plasma and urine (at protein level). Detected in placenta (at protein level). High levels of the proform in placenta and pregnancy serum.in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Post Translational Modifications | Nitrated. |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Protein Name | Bone Marrow Proteoglycan Bmpg Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein Embp Mbp Pregnancy-Associated Major Basic Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Bone Marrow Proteoglycan: Secreted The Proform Is Secreted Eosinophil Granule Major Basic Protein: Cytoplasmic Vesicle Secretory Vesicle The Mature Protein Is Found In The Matrix Of The Eosinophil's Large Specific Granule (Crystalloid Core) |
| Alternative Antibody Names | Anti-Bone Marrow Proteoglycan antibody Anti-Bmpg antibody Anti-Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein antibody Anti-Embp antibody Anti-Mbp antibody Anti-Pregnancy-Associated Major Basic Protein antibody Anti-PRG2 antibody Anti-MBP antibody |
Information sourced from Uniprot.org