| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein-dependent Rac exchanger 1 (340-420 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PREX1 |
| Gene ID: | 57580 |
| Uniprot ID: | PREX1_HUMAN |
| Immunogen Region: | 340-420 aa |
| Specificity: | PREX1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 340-420 |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Protein Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein P-Rex1 Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013406 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasm Cytosol Cell Membrane Mainly Cytosolic Some Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein antibody Anti-P-Rex1 antibody Anti-Ptdins(3 -4 -5-Dependent Rac Exchanger 1 antibody Anti-PREX1 antibody Anti-KIAA1415 antibody |
Information sourced from Uniprot.org