Anti-Prealbumin antibody [11604] (STJ400302)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenNot determined
General Information
| Short Description | Mouse monoclonal anti-Prealbumin for use in FIA and IT in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FIA/IT |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 11604 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 5.0 mg/ml (+/-10 %) |
| Formulation | 50 mM citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Storage Instruction | Store at 2–8 °C, and do not freeze. |
Target Information
| Immunogen | Not determined |
| Specificity | Antibody recognizes human prealbumin. Not determined |
Additional Info
| Tissue Specificity | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | TransthyretinAttrPrealbuminTbpa |
| Database Links | Reactome: R-HSA-2453864Reactome: R-HSA-2453902Reactome: R-HSA-3000171Reactome: R-HSA-6798695Reactome: R-HSA-975634Reactome: R-HSA-977225 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Transthyretin antibodyAnti-Attr antibodyAnti-Prealbumin antibodyAnti-Tbpa antibodyAnti-TTR antibodyAnti-PALB antibody |
Information sourced from Uniprot.org