| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDX6 |
| Gene ID: | 9588 |
| Uniprot ID: | PRDX6_HUMAN |
| Immunogen Region: | 125-224 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 125-224 of human Peroxiredoxin 6 (NP_004896.1). |
| Immunogen Sequence: | KGMPVTARVVFVFGPDKKLK LSILYPATTGRNFDEILRVV ISLQLTAEKRVATPVDWKDG DSVMVLPTIPEEEAKKLFPK GVFTKELPSGKKYLRYTPQP |
| Post Translational Modifications | Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress. Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme. The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate. |
| Protein Name | Peroxiredoxin-6 1-Cys Peroxiredoxin 1-Cys Prx 24 Kda Protein Acidic Calcium-Independent Phospholipase A2 Aipla2 Antioxidant Protein 2 Glutathione-Dependent Peroxiredoxin Liver 2d Page Spot 40 Lysophosphatidylcholine Acyltransferase 5 Lpc Acyltransferase 5 Lpcat-5 Lyso-Pc Acyltransferase 5 Non-Selenium Glutathione Peroxidase Nsgpx Red Blood Cells Page Spot 12 |
| Database Links | Reactome: R-HSA-3299685 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasm Lysosome Also Found In Lung Secretory Organelles (Lamellar Bodies) |
| Alternative Antibody Names | Anti-Peroxiredoxin-6 antibody Anti-1-Cys Peroxiredoxin antibody Anti-1-Cys Prx antibody Anti-24 Kda Protein antibody Anti-Acidic Calcium-Independent Phospholipase A2 antibody Anti-Aipla2 antibody Anti-Antioxidant Protein 2 antibody Anti-Glutathione-Dependent Peroxiredoxin antibody Anti-Liver 2d Page Spot 40 antibody Anti-Lysophosphatidylcholine Acyltransferase 5 antibody Anti-Lpc Acyltransferase 5 antibody Anti-Lpcat-5 antibody Anti-Lyso-Pc Acyltransferase 5 antibody Anti-Non-Selenium Glutathione Peroxidase antibody Anti-Nsgpx antibody Anti-Red Blood Cells Page Spot 12 antibody Anti-PRDX6 antibody Anti-AOP2 antibody Anti-KIAA0106 antibody |
Information sourced from Uniprot.org