Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-PRDX4 (38-271) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PRDX4 |
Gene ID: |
10549 |
Uniprot ID: |
PRDX4_HUMAN |
Immunogen Region: |
38-271 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 38-271 of human Peroxiredoxin 4 (Peroxiredoxin 4 (PRDX4) ) (NP_006397.1). |
Immunogen Sequence: |
WETEERPRTREEECHFYAGG QVYPGEASRVSVADHSLHLS KAKISKPAPYWEGTAVIDGE FKELKLTDYRGKYLVFFFYP LDFTFVCPTEIIAFGDRLEE FRSINTEVVACSVDSQFTHL AWINTPRRQGGLGPIRIPLL SDLTHQISKDYGVYLEDSGH TLRGLFIIDDKGILRQITLN DLPVGRSVDETLRLVQAFQY TDKHGEVCPAGWKPGSETII PDPAGKLKYFDKLN |
Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. |
Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
Protein Name | Peroxiredoxin-4Antioxidant Enzyme Aoe372Aoe37-2Peroxiredoxin IvPrx-IvThioredoxin Peroxidase Ao372Thioredoxin-Dependent Peroxide Reductase A0372Thioredoxin-Dependent Peroxiredoxin 4 |
Database Links | Reactome: R-HSA-6798695 |
Cellular Localisation | CytoplasmEndoplasmic ReticulumCotranslationally Translocated To And Retained Within The Endoplasmic ReticulumA Small Fraction Of The Protein Is Cytoplasmic |
Alternative Antibody Names | Anti-Peroxiredoxin-4 antibodyAnti-Antioxidant Enzyme Aoe372 antibodyAnti-Aoe37-2 antibodyAnti-Peroxiredoxin Iv antibodyAnti-Prx-Iv antibodyAnti-Thioredoxin Peroxidase Ao372 antibodyAnti-Thioredoxin-Dependent Peroxide Reductase A0372 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 4 antibodyAnti-PRDX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance