Anti-PRDX4 antibody (1-100) [S1MR] (STJ11102431)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Peroxiredoxin 4 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRDX4 |
| Gene ID | 10549 |
| Uniprot ID | PRDX4_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MEALPLLAATTPDHGRHRRL LLLPLLLFLLPAGAVQGWET EERPRTREEECHFYAGGQVY PGEASRVSVADHSLHLSKAK ISKPAPYWEGTAVIDGEFKE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Peroxiredoxin 4 (PRDX4) (PRDX4) (Q13162). |
Additional Info
| Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
| Protein Name | Peroxiredoxin-4Antioxidant Enzyme Aoe372Aoe37-2Peroxiredoxin IvPrx-IvThioredoxin Peroxidase Ao372Thioredoxin-Dependent Peroxide Reductase A0372Thioredoxin-Dependent Peroxiredoxin 4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumCotranslationally Translocated To And Retained Within The Endoplasmic ReticulumA Small Fraction Of The Protein Is Cytoplasmic |
| Alternative Antibody Names | Anti-Peroxiredoxin-4 antibodyAnti-Antioxidant Enzyme Aoe372 antibodyAnti-Aoe37-2 antibodyAnti-Peroxiredoxin Iv antibodyAnti-Prx-Iv antibodyAnti-Thioredoxin Peroxidase Ao372 antibodyAnti-Thioredoxin-Dependent Peroxide Reductase A0372 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 4 antibodyAnti-PRDX4 antibody |
Information sourced from Uniprot.org