Anti-PRDX3 antibody (63-256) (STJ115041)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRDX3 (63-256) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRDX3 |
| Gene ID | 10935 |
| Uniprot ID | PRDX3_HUMAN |
| Immunogen Region | 63-256 |
| Immunogen Sequence | PAVTQHAPYFKGTAVVNGEF KDLSLDDFKGKYLVLFFYPL DFTFVCPTEIVAFSDKANEF HDVNCEVVAVSVDSHFSHLA WINTPRKNGGLGHMNIALLS DLTKQISRDYGVLLEGSGLA LRGLFIIDPNGVIKHLSVND LPVGRSVEETLRLVKAFQYV ETHGEVCPANWTPDSPTIKP SPAASKEYFQKVNQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 63-256 of human Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3) ) (NP_006784.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by LRRK2.phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength. |
| Protein Name | Thioredoxin-Dependent Peroxide Reductase - MitochondrialAntioxidant Protein 1Aop-1Hbc189Peroxiredoxin IiiPrx-IiiPeroxiredoxin-3Protein Mer5 HomologThioredoxin-Dependent Peroxiredoxin 3 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | MitochondrionCytoplasmEarly EndosomeLocalizes To Early Endosomes In A Rps6kc1-Dependent Manner |
| Alternative Antibody Names | Anti-Thioredoxin-Dependent Peroxide Reductase - Mitochondrial antibodyAnti-Antioxidant Protein 1 antibodyAnti-Aop-1 antibodyAnti-Hbc189 antibodyAnti-Peroxiredoxin Iii antibodyAnti-Prx-Iii antibodyAnti-Peroxiredoxin-3 antibodyAnti-Protein Mer5 Homolog antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 3 antibodyAnti-PRDX3 antibodyAnti-AOP1 antibody |
Information sourced from Uniprot.org