| Post Translational Modifications | Phosphorylated by LRRK2.phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength. |
| Protein Name | Thioredoxin-Dependent Peroxide Reductase - MitochondrialAntioxidant Protein 1Aop-1Hbc189Peroxiredoxin IiiPrx-IiiPeroxiredoxin-3Protein Mer5 HomologThioredoxin-Dependent Peroxiredoxin 3 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | MitochondrionCytoplasmEarly EndosomeLocalizes To Early Endosomes In A Rps6kc1-Dependent Manner |
| Alternative Antibody Names | Anti-Thioredoxin-Dependent Peroxide Reductase - Mitochondrial antibodyAnti-Antioxidant Protein 1 antibodyAnti-Aop-1 antibodyAnti-Hbc189 antibodyAnti-Peroxiredoxin Iii antibodyAnti-Prx-Iii antibodyAnti-Peroxiredoxin-3 antibodyAnti-Protein Mer5 Homolog antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 3 antibodyAnti-PRDX3 antibodyAnti-AOP1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3) ) knockout (KO) HeLa cells, using [KO Validated] Peroxiredoxin 3 (PRDX3) Rabbit polyclonal antibody (STJ11100034) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/89106/357562/STJ11100034_1__50139.1713121688.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3) ) knockout (KO) HeLa cells, using [KO Validated] Peroxiredoxin 3 (PRDX3) Rabbit polyclonal antibody (STJ11100034) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
![Western blot analysis of lysates from wild type (WT) and Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3) ) knockout (KO) HeLa cells, using [KO Validated] Peroxiredoxin 3 (PRDX3) Rabbit polyclonal antibody (STJ11100034) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/89106/357562/STJ11100034_1__50139.1713121688.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3) ) knockout (KO) HeLa cells, using [KO Validated] Peroxiredoxin 3 (PRDX3) Rabbit polyclonal antibody (STJ11100034) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
