Host: | Rabbit |
Applications: | WB/IHC-P/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PRDM5 |
Gene ID: | 11107 |
Uniprot ID: | PRDM5_HUMAN |
Immunogen Region: | 1-100 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PRDM5 (NP_061169.2). |
Immunogen Sequence: | MLGMYVPDRFSLKSSRVQDG MGLYTARRVRKGEKFGPFAG EKRMPEDLDENMDYRLMWEV RGSKGEVLYILDATNPRHSN WLRFVHEAPSQEQKNLAAIQ |
Tissue Specificity | Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues. |
Function | Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. |
Protein Name | Pr Domain Zinc Finger Protein 5Pr Domain-Containing Protein 5 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 5 antibodyAnti-Pr Domain-Containing Protein 5 antibodyAnti-PRDM5 antibodyAnti-PFM2 antibody |
Information sourced from Uniprot.org