Host: | Rabbit |
Applications: | WB/IP/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PPP4R1 |
Gene ID: | 9989 |
Uniprot ID: | PP4R1_HUMAN |
Immunogen Region: | 324-647 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 324-647 of human PPP4R1 (NP_001035847.1). |
Immunogen Sequence: | NPSSSGQYFKEESKSSEEMS VENKNRTRDQEAPEDVQVRP EDTPSDLSVSNSSVILENTM EDHAAEASGKPLGEISVPLD SSLLCTLSSESHQEAASNEN DKKPGNYKSMLRPEVGTTSQ DSALLDQELYNSFHFWRTPL PEIDLDIELEQNSGGKPSPE GPEEESEGPVPSSPNITMAT RKELEEMIENLEPHIDDPDV KAQVEVLSAALRASSLDAHE ETISIEKRSDLQDELDINE |
Tissue Specificity | Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues. |
Function | Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2. (Microbial infection) Participates in merkel polyomavirus-mediated inhibition of NF-kappa-B by bridging viral small tumor antigen with NEMO. |
Protein Name | Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1 |
Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1 antibodyAnti-PPP4R1 antibodyAnti-MEG1 antibodyAnti-PP4R1 antibody |
Information sourced from Uniprot.org