| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP2R5C |
| Gene ID: | 5527 |
| Uniprot ID: | 2A5G_HUMAN |
| Immunogen Region: | 1-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human PP2A-B56 Gamma/PR61 Gamma/PP2A-B56 Gamma/PR61 Gamma/PPP2R5C (NP_848702.1). |
| Immunogen Sequence: | MLTCNKAGSRMVVDAANSNG PFQPVVLLHIRDVPPADQEK LFIQKLRQCCVLFDFVSDPL SDLKWKEVKRAALSEMVEYI THNRNVITEPIYPEVVHMFA VNMFRTLPPSSNPTGAEFDP EEDEPTLEAAWPHLQLVYEF FLRFLESPDFQPNIAKKYID QKFVLQLLELFDSEDPRERD FLKTTLHRIYGKFLGLRAYI RKQINNIFYRFIYETEHHNG IAELLEILGSIINGFALPL |
| Tissue Specificity | Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver. |
| Post Translational Modifications | Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma IsoformPp2a B Subunit Isoform B'-GammaPp2a B Subunit Isoform B56-GammaPp2a B Subunit Isoform Pr61-GammaPp2a B Subunit Isoform R5-GammaRenal Carcinoma Antigen Ny-Ren-29 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6804757Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromere |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform antibodyAnti-Pp2a B Subunit Isoform B'-Gamma antibodyAnti-Pp2a B Subunit Isoform B56-Gamma antibodyAnti-Pp2a B Subunit Isoform Pr61-Gamma antibodyAnti-Pp2a B Subunit Isoform R5-Gamma antibodyAnti-Renal Carcinoma Antigen Ny-Ren-29 antibodyAnti-PPP2R5C antibodyAnti-KIAA0044 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HeLa cells using [KO Validated] Annexin A5/Annexin V Rabbit polyclonal antibody (STJ22620) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/99134/383749/STJ22620_1__87132.1713152313.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] Annexin A5/Annexin V Rabbit polyclonal antibody (STJ22620) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.")
