| Post Translational Modifications | Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA. |
| Function | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation. Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation. The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H. The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation. The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex. In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex. In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB. |
| Protein Name | Serine/Threonine-Protein Phosphatase 1 Regulatory Subunit 10Mhc Class I Region Proline-Rich Protein Cat53Pp1-Binding Protein Of 114 KdaPhosphatase 1 Nuclear Targeting SubunitP99 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeFound In Discrete Nucleoplasmic Bodies And Within NucleoliAssociates With Rna Polymerase Ii (Pol Ii) On Chromatin During Pause-Release CheckpointAssociates With Chromatin During InterphaseExcluded From Condensed Chromosomes During Early Mitosis And Is Reloaded Onto Chromosomes At The Late Telophase |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 1 Regulatory Subunit 10 antibodyAnti-Mhc Class I Region Proline-Rich Protein Cat53 antibodyAnti-Pp1-Binding Protein Of 114 Kda antibodyAnti-Phosphatase 1 Nuclear Targeting Subunit antibodyAnti-P99 antibodyAnti-PPP1R10 antibodyAnti-CAT53 antibodyAnti-FB19 antibodyAnti-PNUTS antibody |
Information sourced from Uniprot.org
