| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein phosphatase 1A (284-334) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPM1A |
| Gene ID: | 5494 |
| Uniprot ID: | PPM1A_HUMAN |
| Immunogen Region: | 284-334 |
| Specificity: | This antibody detects endogenous levels of human PPM1A |
| Immunogen: | Synthesized peptide derived from human PPM1A AA range: 284-334 |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Protein Name | Protein Phosphatase 1aProtein Phosphatase 2c Isoform AlphaPp2c-AlphaProtein Phosphatase Ia |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-380972 |
| Cellular Localisation | NucleusCytoplasmCytosolMembraneLipid-AnchorWeakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization |
| Alternative Antibody Names | Anti-Protein Phosphatase 1a antibodyAnti-Protein Phosphatase 2c Isoform Alpha antibodyAnti-Pp2c-Alpha antibodyAnti-Protein Phosphatase Ia antibodyAnti-PPM1A antibodyAnti-PPPM1A antibody |
Information sourced from Uniprot.org