| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPL |
| Gene ID: | 5493 |
| Uniprot ID: | PEPL_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PPL (NP_002696.3). |
| Immunogen Sequence: | MNSLFRKRNKGKYSPTVQTR SISNKELSELIEQLQKNADQ VEKNIVDTEAKMQSDLARLQ EGRQPEHRDVTLQKVLDSEK LLYVLEADAAIAKHMKHPQG DMIAEDIRQLKERVTNLRGK HKQIYRLAVK |
| Tissue Specificity | Expressed in stratified squamous epithelia and in some other epithelia. |
| Function | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. |
| Protein Name | Periplakin190 Kda Paraneoplastic Pemphigus Antigen195 Kda Cornified Envelope Precursor Protein |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-8851680 |
| Cellular Localisation | Cell JunctionDesmosomeCytoplasmCytoskeletonCell Membrane |
| Alternative Antibody Names | Anti-Periplakin antibodyAnti-190 Kda Paraneoplastic Pemphigus Antigen antibodyAnti-195 Kda Cornified Envelope Precursor Protein antibodyAnti-PPL antibodyAnti-KIAA0568 antibody |
Information sourced from Uniprot.org