| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPIF (30-207) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPIF |
| Gene ID: |
10105 |
| Uniprot ID: |
PPIF_HUMAN |
| Immunogen Region: |
30-207 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-207 of human PPIF (NP_005720.1). |
| Immunogen Sequence: |
CSKGSGDPSSSSSSGNPLVY LDVDANGKPLGRVVLELKAD VVPKTAENFRALCTGEKGFG YKGSTFHRVIPSFMCQAGDF TNHNGTGGKSIYGSRFPDEN FTLKHVGPGVLSMANAGPNT NGSQFFICTIKTDWLDGKHV VFGHVKEGMDVVKKIESFGS KSGRTSKKIVITDCGQLS |
| Post Translational Modifications | Acetylated at Lys-167.deacetylated at Lys-167 by SIRT3. |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis.the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase F - MitochondrialPpiase FCyclophilin DCyp-DCypdCyclophilin FMitochondrial CyclophilinCyp-MRotamase F |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial antibodyAnti-Ppiase F antibodyAnti-Cyclophilin D antibodyAnti-Cyp-D antibodyAnti-Cypd antibodyAnti-Cyclophilin F antibodyAnti-Mitochondrial Cyclophilin antibodyAnti-Cyp-M antibodyAnti-Rotamase F antibodyAnti-PPIF antibodyAnti-CYP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
