Anti-PPID/CyP-40 antibody (Internal) (STJ71225)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PPID/CyP-40 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 40kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 40.8kDa according to NP_005029.1). Recommended concentration: 0.1-0.3µg/ml. Primary incubation was |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PPID |
| Gene ID | 5481 |
| Uniprot ID | PPID_HUMAN |
| Accession Number | NP_005029.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DENFHYKHDREG |
Additional Info
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer.the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase DPpiase D40 Kda Peptidyl-Prolyl Cis-Trans IsomeraseCyclophilin-40Cyp-40Cyclophilin-Related ProteinRotamase D |
| Database Links | Reactome: R-HSA-8939211 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasm |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase D antibodyAnti-Ppiase D antibodyAnti-40 Kda Peptidyl-Prolyl Cis-Trans Isomerase antibodyAnti-Cyclophilin-40 antibodyAnti-Cyp-40 antibodyAnti-Cyclophilin-Related Protein antibodyAnti-Rotamase D antibodyAnti-PPID antibodyAnti-CYP40 antibodyAnti-CYPD antibody |
Information sourced from Uniprot.org