| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-PPID/CyP-40 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000. WB: Approx 40kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 40.8kDa according to NP_005029.1). Recommended concentration: 0.1-0.3µg/ml. Primary incubation was |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PPID |
| Gene ID: | 5481 |
| Uniprot ID: | PPID_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_005029.1 |
| Immunogen Sequence: | DENFHYKHDREG |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer.the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase D Ppiase D 40 Kda Peptidyl-Prolyl Cis-Trans Isomerase Cyclophilin-40 Cyp-40 Cyclophilin-Related Protein Rotamase D |
| Database Links | Reactome: R-HSA-8939211 |
| Cellular Localisation | Cytoplasm Nucleus Nucleolus Nucleoplasm |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase D antibody Anti-Ppiase D antibody Anti-40 Kda Peptidyl-Prolyl Cis-Trans Isomerase antibody Anti-Cyclophilin-40 antibody Anti-Cyp-40 antibody Anti-Cyclophilin-Related Protein antibody Anti-Rotamase D antibody Anti-PPID antibody Anti-CYP40 antibody Anti-CYPD antibody |
Information sourced from Uniprot.org