| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Liprin-alpha-2 (49-99 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPFIA2 |
| Gene ID: | 8499 |
| Uniprot ID: | LIPA2_HUMAN |
| Immunogen Region: | 49-99 aa |
| Specificity: | This antibody detects endogenous levels of LIPA2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human LIPA2 at the amino acid range 49-99 |
| Function | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines. |
| Protein Name | Liprin-Alpha-2 Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein Alpha-2 Ptprf-Interacting Protein Alpha-2 |
| Database Links | Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-388844 |
| Cellular Localisation | Cytoplasm Cell Surface Cell Projection Dendritic Spine Colocalizes With Ptprf At The Cell Surface |
| Alternative Antibody Names | Anti-Liprin-Alpha-2 antibody Anti-Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein Alpha-2 antibody Anti-Ptprf-Interacting Protein Alpha-2 antibody Anti-PPFIA2 antibody |
Information sourced from Uniprot.org