| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Peroxisome proliferator-activated receptor alpha (6-55 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:10000-20000IHC 1:50-300IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPARA |
| Gene ID: | 5465 |
| Uniprot ID: | PPARA_HUMAN |
| Immunogen Region: | 6-55 aa |
| Specificity: | PPAR-Alpha Polyclonal Antibody detects endogenous levels of PPAR-Alpha protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PPAR-alpha at the amino acid range 6-55 |
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin-protein ligase HUWE1.leading to proteasomal degradation. Phosphorylated. |
| Function | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
| Protein Name | Peroxisome Proliferator-Activated Receptor AlphaPpar-AlphaNuclear Receptor Subfamily 1 Group C Member 1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-4090294Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Alpha antibodyAnti-Ppar-Alpha antibodyAnti-Nuclear Receptor Subfamily 1 Group C Member 1 antibodyAnti-PPARA antibodyAnti-NR1C1 antibodyAnti-PPAR antibody |
Information sourced from Uniprot.org