| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-PP2A-gamma (390-439) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PPP2R5C |
| Gene ID: | 5527 |
| Uniprot ID: | 2A5G_HUMAN |
| Immunogen Region: | 390-439 |
| Immunogen: | Synthetic peptide taken within amino acid region 390-439 on human Serine/Threonine-Protein Phosphatase 2A B56 Gamma1 subunit. |
| Post Translational Modifications | Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform Pp2a B Subunit Isoform B'-Gamma Pp2a B Subunit Isoform B56-Gamma Pp2a B Subunit Isoform Pr61-Gamma Pp2a B Subunit Isoform R5-Gamma Renal Carcinoma Antigen Ny-Ren-29 |
| Database Links | Reactome: R-HSA-141444 Reactome: R-HSA-195253 Reactome: R-HSA-196299 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-389513 Reactome: R-HSA-432142 Reactome: R-HSA-4641262 Reactome: R-HSA-5339716 Reactome: R-HSA-5358747 Reactome: R-HSA-5358749 Reactome: R-HSA-5358751 Reactome: R-HSA-5358752 Reactome: R-HSA-5467337 Reactome: R-HSA-5467340 Reactome: R-HSA-5467348 Reactome: R-HSA-5663220 Reactome: R-HSA-5673000 Reactome: R-HSA-5675221 Reactome: R-HSA-6804757 Reactome: R-HSA-6811558 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 |
| Cellular Localisation | Nucleus Chromosome Centromere |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform antibody Anti-Pp2a B Subunit Isoform B'-Gamma antibody Anti-Pp2a B Subunit Isoform B56-Gamma antibody Anti-Pp2a B Subunit Isoform Pr61-Gamma antibody Anti-Pp2a B Subunit Isoform R5-Gamma antibody Anti-Renal Carcinoma Antigen Ny-Ren-29 antibody Anti-PPP2R5C antibody Anti-KIAA0044 antibody |
Information sourced from Uniprot.org