| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-POU domain, class 2, transcription factor 2 (250-350 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-OCT2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POU2F2 |
| Gene ID: | 5452 |
| Uniprot ID: | PO2F2_HUMAN |
| Immunogen Region: | 250-350 aa |
| Specificity: | This antibody detects endogenous levels of human Oct-2. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: | Synthesized peptide derived from the human Oct-2 at the amino acid range 250-350 |
| Function | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5: Activates the U2 small nuclear RNA (snRNA) promoter. |
| Protein Name | Pou Domain - Class 2 - Transcription Factor 2 Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein Nf-A2 Octamer-Binding Protein 2 Oct-2 Octamer-Binding Transcription Factor 2 Otf-2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 2 - Transcription Factor 2 antibody Anti-Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein Nf-A2 antibody Anti-Octamer-Binding Protein 2 antibody Anti-Oct-2 antibody Anti-Octamer-Binding Transcription Factor 2 antibody Anti-Otf-2 antibody Anti-POU2F2 antibody Anti-OCT2 antibody Anti-OTF2 antibody |
Information sourced from Uniprot.org