| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POT1 (497-634) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POT1 |
| Gene ID: |
25913 |
| Uniprot ID: |
POTE1_HUMAN |
| Immunogen Region: |
497-634 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 497-634 of human POT1 (NP_056265.2). |
| Immunogen Sequence: |
TIHHYGCKQCSSLRSIQNLN SLVDKTSWIPSSVAEALGIV PLQYVFVMTFTLDDGTGVLE AYLMDSDKFFQIPASEVLMD DDLQKSVDMIMDMFCPPGIK IDAYPWLECFIKSYNVTNGT DNQICYQIFDTTVAEDVI |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. |
| Protein Name | Protection Of Telomeres Protein 1Hpot1Pot1-Like Telomere End-Binding Protein |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusChromosomeTelomereColocalizes With Telomeric Dna |
| Alternative Antibody Names | Anti-Protection Of Telomeres Protein 1 antibodyAnti-Hpot1 antibodyAnti-Pot1-Like Telomere End-Binding Protein antibodyAnti-POT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
