Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PON3 |
Gene ID: |
5446 |
Uniprot ID: |
PON3_HUMAN |
Immunogen Region: |
250-350 |
Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
Immunogen Sequence: |
HDNWDLTQLKVIQLGTLVDN LTVDPATGDILAGCHPNPMK LLNYNPEDPPGSEVLRIQNV LSEKPRVSTVYANNGSVLQG TSVASVYHGKILIGTVFHKT L |
Post Translational Modifications | The signal sequence is not cleaved. |
Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
Protein Name | Serum Paraoxonase/Lactonase 3 |
Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
Cellular Localisation | SecretedExtracellular Space |
Alternative Antibody Names | Anti-Serum Paraoxonase/Lactonase 3 antibodyAnti-PON3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance