| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PON3 |
| Gene ID: | 5446 |
| Uniprot ID: | PON3_HUMAN |
| Immunogen Region: | 250-350 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
| Immunogen Sequence: | HDNWDLTQLKVIQLGTLVDN LTVDPATGDILAGCHPNPMK LLNYNPEDPPGSEVLRIQNV LSEKPRVSTVYANNGSVLQG TSVASVYHGKILIGTVFHKT L |
| Post Translational Modifications | The signal sequence is not cleaved. |
| Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
| Protein Name | Serum Paraoxonase/Lactonase 3 |
| Database Links | Reactome: R-HSA-2142688 Reactome: R-HSA-9754706 |
| Cellular Localisation | Secreted Extracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Lactonase 3 antibody Anti-PON3 antibody |
Information sourced from Uniprot.org