| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PON3 |
| Gene ID: |
5446 |
| Uniprot ID: |
PON3_HUMAN |
| Immunogen Region: |
250-350 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
| Immunogen Sequence: |
HDNWDLTQLKVIQLGTLVDN LTVDPATGDILAGCHPNPMK LLNYNPEDPPGSEVLRIQNV LSEKPRVSTVYANNGSVLQG TSVASVYHGKILIGTVFHKT L |
| Post Translational Modifications | The signal sequence is not cleaved. |
| Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
| Protein Name | Serum Paraoxonase/Lactonase 3 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Lactonase 3 antibodyAnti-PON3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
