Western blot analysis of extracts of various cell lines, using PON1 antibody (STJ25056) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-PON1 antibody (9-109) (STJ25056)

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STJ25056
£112.50 - £524.50
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PON1
Gene ID: 5444
Uniprot ID: PON1_HUMAN
Immunogen Region: 9-109
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 9-109 of human PON1 (NP_000437.3).
Immunogen Sequence: LLGMGLALFRNHQSSYQTRL NALREVQPVELPNCNLVKGI ETGSEDLEILPNGLAFISSG LKYPGIKSFNPNSPGKILLM DLNEEDPTVLELGITGSKFD V
Tissue Specificity Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
Post Translational Modifications Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not.
Function Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Protein Name Serum Paraoxonase/Arylesterase 1
Pon 1
Aromatic Esterase 1
A-Esterase 1
K-45
Serum Aryldialkylphosphatase 1
Database Links Reactome: R-HSA-2142688
Reactome: R-HSA-9754706
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Serum Paraoxonase/Arylesterase 1 antibody
Anti-Pon 1 antibody
Anti-Aromatic Esterase 1 antibody
Anti-A-Esterase 1 antibody
Anti-K-45 antibody
Anti-Serum Aryldialkylphosphatase 1 antibody
Anti-PON1 antibody
Anti-PON antibody

Information sourced from Uniprot.org

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