Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PON1 |
Gene ID: | 5444 |
Uniprot ID: | PON1_HUMAN |
Immunogen Region: | 20-150 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PON1 (NP_000437.3). |
Immunogen Sequence: | HQSSYQTRLNALREVQPVEL PNCNLVKGIETGSEDLEILP NGLAFISSGLKYPGIKSFNP NSPGKILLMDLNEEDPTVLE LGITGSKFDVSSFNPHGIST FTDEDNAMYLLVVNHPDAKS TVELFKFQEEE |
Tissue Specificity | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
Post Translational Modifications | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
Protein Name | Serum Paraoxonase/Arylesterase 1 Pon 1 Aromatic Esterase 1 A-Esterase 1 K-45 Serum Aryldialkylphosphatase 1 |
Database Links | Reactome: R-HSA-2142688 Reactome: R-HSA-9754706 |
Cellular Localisation | Secreted Extracellular Space |
Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 1 antibody Anti-Pon 1 antibody Anti-Aromatic Esterase 1 antibody Anti-A-Esterase 1 antibody Anti-K-45 antibody Anti-Serum Aryldialkylphosphatase 1 antibody Anti-PON1 antibody Anti-PON antibody |
Information sourced from Uniprot.org