| Tissue Specificity | Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. |
| Function | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. |
| Protein Name | Protein O-Mannose KinasePomkProtein Kinase-Like Protein Sgk196Sugen Kinase 196 |
| Database Links | Reactome: R-HSA-5173105 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Protein O-Mannose Kinase antibodyAnti-Pomk antibodyAnti-Protein Kinase-Like Protein Sgk196 antibodyAnti-Sugen Kinase 196 antibodyAnti-POMK antibodyAnti-SGK196 antibody |
Information sourced from Uniprot.org
