Anti-Poly Polymerase antibody [A6.4.12] (STJ16100843)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenHuman PARP-1
General Information
| Short Description | Mouse monoclonal anti-Poly Polymerase for use in WB, IHC-P, IP, IHC-F, ELISA and IF in Human, D.melanogaster, Hamster, Mouse, Rat and Xenopus samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP/IHC-F/ELISA/IF |
| Host | Mouse |
| Reactivity | Human/D.melanogaster/Hamster/Mouse/Rat/Xenopus |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | A6.4.12 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1.0 mg/mL |
| Formulation | PBS with 0.09% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Human PARP-1 |
Additional Info
| Background | Mouse anti poly (ADP-ribose) polymerase 1 antibody, clone A6.4.12 recognizes poly (ADP-ribose) polymerase 1 (PARP-1) , a ~116 kDa nuclear enzyme, cleaved during apoptosis (Soldani et al. 2002). PARP-1, a caretaker enzyme, is involved in DNA damage repair (Langelier et al. 2013) , plays roles in diabetes pathophysiology (Andreone et al. 2012) and tumour proliferation (Rosado et al 2013.).As well as protecting cells from genomic instability, PARP-1 is involved in the development of both inflammatory and immune responses, and cell death by apoptosis and necrosis (Erdélyi et al. 2005). Mouse anti poly (ADP-ribose) polymerase 1 antibody, clone A6.4.12, targets PARP-1, an enzyme which represents a promising target for new developments in therapeutic treatment of immune mediated diseases (Rosado et al. 2013). PARP-1 has considerable potential for delivering selective tumour cell killing while sparing normal cells (Pinton et al. 2013). |
Information sourced from Uniprot.org