| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR3K |
| Gene ID: |
51728 |
| Uniprot ID: |
RPC10_HUMAN |
| Immunogen Region: |
1-108 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-108 of human POLR3K (NP_057394.3). |
| Immunogen Sequence: |
MLLFCPGCGNGLIVEEGQRC HRFACNTCPYVHNITRKVTN RKYPKLKEVDDVLGGAAAWE NVDSTAESCPKCEHPRAYFM QLQTRSADEPMTTFYKCCNA QCGHRWRD |
| Function | Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc10Rna Polymerase Iii Subunit C10Dna-Directed Rna Polymerase Iii Subunit KRna Polymerase Iii 12.5 Kda SubunitRpc12.5Rna Polymerase Iii Subunit C11Hsc11pRpc11Hrpc11 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase Iii Subunit Rpc10 antibodyAnti-Rna Polymerase Iii Subunit C10 antibodyAnti-Dna-Directed Rna Polymerase Iii Subunit K antibodyAnti-Rna Polymerase Iii 12.5 Kda Subunit antibodyAnti-Rpc12.5 antibodyAnti-Rna Polymerase Iii Subunit C11 antibodyAnti-Hsc11p antibodyAnti-Rpc11 antibodyAnti-Hrpc11 antibodyAnti-POLR3K antibodyAnti-RPC11 antibodyAnti-My010 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
