| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POLR1B (670-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POLR1B |
| Gene ID: |
84172 |
| Uniprot ID: |
RPA2_HUMAN |
| Immunogen Region: |
670-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 670-900 of human POLR1B (NP_061887.2). |
| Immunogen Sequence: |
IANFIPFSDHNQSPRNMYQC QMGKQTMGFPLLTYQDRSDN KLYRLQTPQSPLVRPSMYDY YDMDNYPIGTNAIVAVISYT GYDMEDAMIVNKASWERGFA HGSVYKSEFIDLSEKIKQGD SSLVFGIKPGDPRVLQKLDD DGLPFIGAKLQYGDPYYSYL NLNTGESFVMYYKSKENCVV DNIKVCSNDTGSGKFKCVCI TMRVPRNPTIGDKFASRHGQ KGILSRLWPAE |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. |
| Protein Name | Dna-Directed Rna Polymerase I Subunit Rpa2Rna Polymerase I Subunit 2Dna-Directed Rna Polymerase I 135 Kda PolypeptideRpa135 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolusChromosome |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase I Subunit Rpa2 antibodyAnti-Rna Polymerase I Subunit 2 antibodyAnti-Dna-Directed Rna Polymerase I 135 Kda Polypeptide antibodyAnti-Rpa135 antibodyAnti-POLR1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
