| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DNA polymerase kappa (272-322 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLK |
| Gene ID: | 51426 |
| Uniprot ID: | POLK_HUMAN |
| Immunogen Region: | 272-322 aa |
| Specificity: | This antibody detects endogenous levels of POLK at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human POLK at the amino acid range 272-322 |
| Function | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. |
| Protein Name | Dna Polymerase KappaDinb ProteinDinp |
| Database Links | Reactome: R-HSA-5655862Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210 |
| Cellular Localisation | NucleusDetected Throughout The Nucleus And At Replication FociRecruited To Dna Damage Sites In Response To Ultraviolet Irradiation: N6-Methyladenosine (M6a)-Containing Mrnas Accumulate In The Vicinity Of Dna Damage Sites And Their Presence Is Required To Recruit Polk |
| Alternative Antibody Names | Anti-Dna Polymerase Kappa antibodyAnti-Dinb Protein antibodyAnti-Dinp antibodyAnti-POLK antibodyAnti-DINB1 antibody |
Information sourced from Uniprot.org
