| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:10-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLG2 |
| Gene ID: | 11232 |
| Uniprot ID: | DPOG2_HUMAN |
| Immunogen Region: | 216-485 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 216-485 of human POLG2 (NP_009146.2). |
| Immunogen Sequence: | HPVFDTKQIRNGVKSIGEKT EASLVWFTPPRTSNQWLDFW LRHRLQWWRKFAMSPSNFSS SDCQDEEGRKGNKLYYNFPW GKELIETLWNLGDHELLHMY PGNVSKLHGRDGRKNVVPCV LSVNGDLDRGMLAYLYDSFQ LTENSFTRKKNLHRKVLKLH PCLAPIKVALDVGRGPTLEL RQVCQGLFNELLENGISVWP GYLETMQSSLEQLYSKYDEM SILFTVLVTETTLENGLIH |
| Function | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. |
| Protein Name | Dna Polymerase Subunit Gamma-2 Dna Polymerase Gamma Accessory 55 Kda Subunit P55 Mitochondrial Dna Polymerase Accessory Subunit Mtpolb Polg-Beta |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion Mitochondrion Matrix Mitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Dna Polymerase Subunit Gamma-2 antibody Anti-Dna Polymerase Gamma Accessory 55 Kda Subunit antibody Anti-P55 antibody Anti-Mitochondrial Dna Polymerase Accessory Subunit antibody Anti-Mtpolb antibody Anti-Polg-Beta antibody Anti-POLG2 antibody Anti-MTPOLB antibody |
Information sourced from Uniprot.org