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Anti-POLD4 antibody (43-93 aa) (STJ196496)

Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°C over night
Immunohistochemical analysis of paraffin-embedded human Small intestinal stromal tumor. 1, Tris-EDTA, pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200 (4°C overnight. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-POLD4 antibody (43-93 aa) (STJ196496)

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STJ196496

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNA polymerase delta subunit 4 (43-93 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	POLD4
Gene ID:	57804
Uniprot ID:	DPOD4_HUMAN
Immunogen Region:	43-93 aa
Specificity:	This antibody detects endogenous levels of human POLD4
Immunogen:	Synthesized peptide derived from the human POLD4 at the amino acid range 43-93

Function	As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites. Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival.
Protein Name	Dna Polymerase Delta Subunit 4 Dna Polymerase Delta Subunit P12
Database Links	Reactome: R-HSA-110314 Reactome: R-HSA-174411 Reactome: R-HSA-174414 Reactome: R-HSA-174417 Reactome: R-HSA-174437 Reactome: R-HSA-5358565 Reactome: R-HSA-5358606 Reactome: R-HSA-5651801 Reactome: R-HSA-5656169 Reactome: R-HSA-5685942 Reactome: R-HSA-5696397 Reactome: R-HSA-5696400 Reactome: R-HSA-6782135 Reactome: R-HSA-6782210 Reactome: R-HSA-69091 Reactome: R-HSA-69166 Reactome: R-HSA-69183
Cellular Localisation	Nucleus Partially Recruited To Dna Damage Sites Within 2 Hours Following Uv Irradiation Before Degradation
Alternative Antibody Names	Anti-Dna Polymerase Delta Subunit 4 antibody Anti-Dna Polymerase Delta Subunit P12 antibody Anti-POLD4 antibody Anti-POLDS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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