| Function | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane. |
| Protein Name | Protein O-Glucosyltransferase 1Cap10-Like 46 Kda ProteinHclp46Ktel Motif-Containing Protein 1Myelodysplastic Syndromes Relative ProteinO-Glucosyltransferase Rumi HomologHrumiProtein O-Xylosyltransferase Poglut1 |
| Database Links | Reactome: R-HSA-1912399 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Protein O-Glucosyltransferase 1 antibodyAnti-Cap10-Like 46 Kda Protein antibodyAnti-Hclp46 antibodyAnti-Ktel Motif-Containing Protein 1 antibodyAnti-Myelodysplastic Syndromes Relative Protein antibodyAnti-O-Glucosyltransferase Rumi Homolog antibodyAnti-Hrumi antibodyAnti-Protein O-Xylosyltransferase Poglut1 antibodyAnti-POGLUT1 antibodyAnti-C3orf9 antibodyAnti-CLP46 antibodyAnti-KTELC1 antibodyAnti-MDSRP antibodyAnti-MDS010 antibodyAnti-UNQ490 antibodyAnti-PRO1006 antibody |
Information sourced from Uniprot.org
