| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-PNOC (27-38) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Not yet tested-our routinely used western blotting protocol does not allow detection of mature proteins much smaller than the calculated size of 20.3kDa according to the precursor NP_ |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PNOC |
| Gene ID: | 5368 |
| Uniprot ID: | PNOC_HUMAN |
| Immunogen Region: | 27-38 |
| Accession Number: | NP_006219.1 |
| Immunogen Sequence: | TCQEKLHPALDS |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
| Function | Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. |
| Protein Name | Prepronociceptin Cleaved Into - Nocistatin - NociceptinOrphanin FqPpnoc - Orphanin Fq2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Prepronociceptin Cleaved Into - Nocistatin - Nociceptin antibodyAnti-Orphanin Fq antibodyAnti-Ppnoc - Orphanin Fq2 antibodyAnti-PNOC antibodyAnti-OFQ antibody |
Information sourced from Uniprot.org