| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PNOC (20-176) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PNOC |
| Gene ID: |
5368 |
| Uniprot ID: |
PNOC_HUMAN |
| Immunogen Region: |
20-176 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-176 of human PNOC (NP_006219.1). |
| Immunogen Sequence: |
SCQRDCLTCQEKLHPALDSF DLEVCILECEEKVFPSPLWT PCTKVMARSSWQLSPAAPEH VAAALYQPRASEMQHLRRMP RVRSLFQEQEEPEPGMEEAG EMEQKQLQKRFGGFTGARKS ARKLANQKRFSEFMRQYLVL SMQSSQRRRTLHQNGNV |
| Tissue Specificity | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
| Function | Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. |
| Protein Name | Prepronociceptin Cleaved Into - Nocistatin - NociceptinOrphanin FqPpnoc - Orphanin Fq2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Prepronociceptin Cleaved Into - Nocistatin - Nociceptin antibodyAnti-Orphanin Fq antibodyAnti-Ppnoc - Orphanin Fq2 antibodyAnti-PNOC antibodyAnti-OFQ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
