| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PNO1 (1-252) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PNO1 |
| Gene ID: |
56902 |
| Uniprot ID: |
PNO1_HUMAN |
| Immunogen Region: |
1-252 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human PNO1 (NP_064528.1). |
| Immunogen Sequence: |
MESEMETQSARAEEGFTQVT RKGGRRAKKRQAEQLSAAGE GGDAGRMDTEEARPAKRPVF PPLCGDGLLSGKEETRKIPV PANRYTPLKENWMKIFTPIV EHLGLQIRFNLKSRNVEIRT CKETKDVSALTKAADFVKAF ILGFQVEDALALIRLDDLFL ESFEITDVKPLKGDHLSRAI GRIAGKGGKTKFTIENVTRT RIVLADVKVHILGSFQNIKM ARTAICNLILGNPPSKVYG |
| Tissue Specificity | Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. |
| Protein Name | Rna-Binding Protein Pno1Partner Of Nob1 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Rna-Binding Protein Pno1 antibodyAnti-Partner Of Nob1 antibodyAnti-PNO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
