Anti-PNO1 antibody (1-252) (STJ119777)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PNO1 (1-252) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNO1 |
| Gene ID | 56902 |
| Uniprot ID | PNO1_HUMAN |
| Immunogen Region | 1-252 |
| Immunogen Sequence | MESEMETQSARAEEGFTQVT RKGGRRAKKRQAEQLSAAGE GGDAGRMDTEEARPAKRPVF PPLCGDGLLSGKEETRKIPV PANRYTPLKENWMKIFTPIV EHLGLQIRFNLKSRNVEIRT CKETKDVSALTKAADFVKAF ILGFQVEDALALIRLDDLFL ESFEITDVKPLKGDHLSRAI GRIAGKGGKTKFTIENVTRT RIVLADVKVHILGSFQNIKM ARTAICNLILGNPPSKVYG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human PNO1 (NP_064528.1). |
Additional Info
| Tissue Specificity | Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. |
| Protein Name | Rna-Binding Protein Pno1Partner Of Nob1 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Rna-Binding Protein Pno1 antibodyAnti-Partner Of Nob1 antibodyAnti-PNO1 antibody |
Information sourced from Uniprot.org