| Tissue Specificity | Pancreas. |
| Function | Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. |
| Protein Name | Pancreatic Lipase-Related Protein 2Pl-Rp2Cytotoxic T Lymphocyte LipaseGalactolipaseTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-192456 |
| Cellular Localisation | SecretedZymogen Granule MembranePeripheral Membrane ProteinCell ProjectionNeuron ProjectionLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Pancreatic Lipase-Related Protein 2 antibodyAnti-Pl-Rp2 antibodyAnti-Cytotoxic T Lymphocyte Lipase antibodyAnti-Galactolipase antibodyAnti-Triacylglycerol Lipase antibodyAnti-PNLIPRP2 antibodyAnti-PLRP2 antibody |
Information sourced from Uniprot.org
