| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PNLIPRP2 (301-470) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PNLIPRP2 |
| Gene ID: |
5408 |
| Uniprot ID: |
LIPR2_HUMAN |
| Immunogen Region: |
301-470 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 301-470 of human PNLIPRP2 (NP_005387.2). |
| Immunogen Sequence: |
LGYPCASYDEFQESKCFPCP AEGCPKMGHYADQFKGKTSA VEQTFFLNTGESGNFTSWRY KVSVTLSGKEKVNGYIRIAL YGSNENSKQYEIFKGSLKPD ASHTCAIDVDFNVGKIQKVK FLWNKRGINLSEPKLGASQI TVQSGEDGTEYNFCSSDTVE ENVLQSLYPC |
| Tissue Specificity | Pancreas. |
| Function | Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. |
| Protein Name | Pancreatic Lipase-Related Protein 2Pl-Rp2Cytotoxic T Lymphocyte LipaseGalactolipaseTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-192456 |
| Cellular Localisation | SecretedZymogen Granule MembranePeripheral Membrane ProteinCell ProjectionNeuron ProjectionLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Pancreatic Lipase-Related Protein 2 antibodyAnti-Pl-Rp2 antibodyAnti-Cytotoxic T Lymphocyte Lipase antibodyAnti-Galactolipase antibodyAnti-Triacylglycerol Lipase antibodyAnti-PNLIPRP2 antibodyAnti-PLRP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
