| Short Description : | Rabbit polyclonal PMVK (1-192) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PMVK |
| Gene ID: | 10654 |
| Uniprot ID: | PMVK_HUMAN |
| Immunogen Region: | 1-192 |
| Immunogen Sequence: | MAPLGGAPRLVLLFSGKRKS GKDFVTEALQSRLGADVCAV LRLSGPLKEQYAQEHGLNFQ RLLDTSTYKEAFRKDMIRWG EEKRQADPGFFCRKIVEGIS QPIWLVSDTRRVSDIQWFRE AYGAVTQTVRVVALEQSRQQ RGWVFTPGVDDAESECGLDN FGDFDWVIENHGVEQRLEEQ LENLIEFIRSRL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1). |
| Tissue Specificity | Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. |
| Function | Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. |
| Protein Name | Phosphomevalonate KinasePmkaseHpmk |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Phosphomevalonate Kinase antibodyAnti-Pmkase antibodyAnti-Hpmk antibodyAnti-PMVK antibodyAnti-PMKI antibody |
Information sourced from Uniprot.org
