| Short Description : | Rabbit polyclonal PMPCB (110-380) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PMPCB |
| Gene ID: | 9512 |
| Uniprot ID: | MPPB_HUMAN |
| Immunogen Region: | 110-380 |
| Immunogen Sequence: | GTKKRSQLDLELEIENMGAH LNAYTSREQTVYYAKAFSKD LPRAVEILADIIQNSTLGEA EIERERGVILREMQEVETNL QEVVFDYLHATAYQNTALGR TILGPTENIKSISRKDLVDY ITTHYKGPRIVLAAAGGVSH DELLDLAKFHFGDSLCTHKG EIPALPPCKFTGSEIRVRDD KMPLAHLAIAVEAVGWAHPD TICLMVANTLIGNWDRSFGG GMNLSSKLAQLTCHGNLCH |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2). |
| Function | Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis. |
| Protein Name | Mitochondrial-Processing Peptidase Subunit BetaBeta-MppP-52 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-8949664 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Mitochondrial-Processing Peptidase Subunit Beta antibodyAnti-Beta-Mpp antibodyAnti-P-52 antibodyAnti-PMPCB antibodyAnti-MPPB antibody |
Information sourced from Uniprot.org
