• Immunohistochemistry analysis of PMEPA1 in paraffin-embedded mouse lung using PMEPA1 Rabbit polyclonal antibody (STJ118982) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of PMEPA1 in paraffin-embedded human placenta using PMEPA1 Rabbit polyclonal antibody (STJ118982) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of PMEPA1 in paraffin-embedded rat ovary using PMEPA1 Rabbit polyclonal antibody (STJ118982) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-PMEPA1 antibody (173-252) (STJ118982)

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STJ118982

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PMEPA1 (173-252) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PMEPA1
Gene ID: 56937
Uniprot ID: PMEPA_HUMAN
Immunogen Region: 173-252
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 173-252 of human PMEPA1 (NP_954638.1).
Immunogen Sequence: PSSNSGISATCYGSGGRMEG PPPTYSEVIGHYPGSSFQHQ QSSGPPSLLEGTRLHHTHIA PLESAAIWSKEKDKQKGHPL
Tissue Specificity Highest expression in prostate. Also expressed in ovary.
Function Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.
Protein Name Protein Tmepai
Prostate Transmembrane Protein Androgen Induced 1
Solid Tumor-Associated 1 Protein
Transmembrane Prostate Androgen-Induced Protein
Database Links Reactome: R-HSA-2173788
Cellular Localisation Early Endosome Membrane
Single-Pass Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Protein Tmepai antibody
Anti-Prostate Transmembrane Protein Androgen Induced 1 antibody
Anti-Solid Tumor-Associated 1 Protein antibody
Anti-Transmembrane Prostate Androgen-Induced Protein antibody
Anti-PMEPA1 antibody
Anti-STAG1 antibody
Anti-TMEPAI antibody

Information sourced from Uniprot.org

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