| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PMCH (22-165) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PMCH |
| Gene ID: |
5367 |
| Uniprot ID: |
MCH_HUMAN |
| Immunogen Region: |
22-165 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-165 of human PMCH (NP_002665.2). |
| Immunogen Sequence: |
ILLSASKSIRNLDDDMVFNT FRLGKGFQKEDTAEKSVIAP SLEQYKNDESSFMNEEENKV SKNTGSKHNFLNHGLPLNLA IKPYLALKGSVAFPAENGVQ NTESTQEKREIGDEENSAKF PIGRRDFDMLRCMLGRVYRP CWQV |
| Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. |
| Post Translational Modifications | Differentially processed in the brain and in peripheral organs producing two neuropeptides.NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. |
| Protein Name | Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic AcidNgeNeuropeptide G-E - Neuropeptide-Glutamic Acid-IsoleucineNeiNeuropeptide E-I - Melanin-Concentrating HormoneMch |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Mch Cleaved Into - Neuropeptide-Glycine-Glutamic Acid antibodyAnti-Nge antibodyAnti-Neuropeptide G-E - Neuropeptide-Glutamic Acid-Isoleucine antibodyAnti-Nei antibodyAnti-Neuropeptide E-I - Melanin-Concentrating Hormone antibodyAnti-Mch antibodyAnti-PMCH antibodyAnti-MCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
