| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLXNA3 (950-1150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLXNA3 |
| Gene ID: |
55558 |
| Uniprot ID: |
PLXA3_HUMAN |
| Immunogen Region: |
950-1150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human PLXNA3 (NP_059984.3). |
| Immunogen Sequence: |
GTRLTISGSSLDAGSRVTVT VRDSECQFVRRDAKAIVCIS PLSTLGPSQAPITLAIDRAN ISSPGLIYTYTQDPTVTRLE PTWSIINGSTAITVSGTHLL TVQEPRVRAKYRGIETTNTC QVINDTAMLCKAPGIFLGRP QPRAQGEHPDEFGFLLDHVQ TARSLNRSSFTYYPDPSFEP LGPSGVLDVKPGSHVVLKGK N |
| Function | Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| Protein Name | Plexin-A3Plexin-4Semaphorin Receptor Sex |
| Database Links | Reactome: R-HSA-399954Reactome: R-HSA-399955Reactome: R-HSA-399956 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Plexin-A3 antibodyAnti-Plexin-4 antibodyAnti-Semaphorin Receptor Sex antibodyAnti-PLXNA3 antibodyAnti-PLXN4 antibodyAnti-SEX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
