Anti-PLOD3 antibody (25-306) [S4161RM] (STJ11104161)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes-Procollagen-Lysine-2-Oxoglutarate 5-Dioxygenase 3 (25-306) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilu |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4161RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLOD3 |
| Gene ID | 8985 |
| Uniprot ID | PLOD3_HUMAN |
| Immunogen Region | 25-306 |
| Immunogen Sequence | SDRPRGRDPVNPEKLLVITV ATAETEGYLRFLRSAEFFNY TVRTLGLGEEWRGGDVARTV GGGQKVRWLKKEMEKYADRE DMIIMFVDSYDVILAGSPTE LLKKFVQSGSRLLFSAESFC WPEWGLAEQYPEVGTGKRFL NSGGFIGFATTIHQIVRQWK YKDDDDDQLFYTRLYLDPGL REKLSLNLDHKSRIFQNLNG ALDEVVLKFDRNRVRIRNVA YDTLPIVVHGNGPTKLQLN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 25-306 of human PLOD3 (NP_001075.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Detected in heart, placenta and pancreas and at lower levels in lung, liver and skeletal muscle. |
| Function | Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine. Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes. |
| Protein Name | Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3Lysyl Hydroxylase 3Lh3 - Procollagen GlycosyltransferaseGalactosylhydroxylysine-GlucosyltransferaseProcollagen GalactosyltransferaseProcollagen Glucosyltransferase |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Rough Endoplasmic ReticulumEndoplasmic Reticulum LumenEndoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideSecretedExtracellular SpaceThe Majority Of The Secreted Protein Is Associated With The Extracellular Matrix |
| Alternative Antibody Names | Anti-Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3 antibodyAnti-Lysyl Hydroxylase 3 antibodyAnti-Lh3 - Procollagen Glycosyltransferase antibodyAnti-Galactosylhydroxylysine-Glucosyltransferase antibodyAnti-Procollagen Galactosyltransferase antibodyAnti-Procollagen Glucosyltransferase antibodyAnti-PLOD3 antibody |
Information sourced from Uniprot.org