Anti-PLIN5 antibody [SRP15095] (STJ11109825)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit polyclonal PLIN5 antibody for use in WB, IF-P, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF-P/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Clone ID | SRP15095 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:3000IF-P, 1:100-1:300IHC-P, 1:500-1:2000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000) , a |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Plin5 |
| Gene ID | 66968 |
| Uniprot ID | PLIN5_MOUSE |
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Highly expressed in oxidative tissues, including heart, liver, brown adipose tissue (BAT) and slow-twitch fibers of skeletal muscle. Lower expression in epididymal white adipose tissue and anterior tibialis and quadriceps. Expressed in adrenal glands. Isoform 2 has the highest expression in heart. |
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or with lipolytic stimulation. |
| Function | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. |
| Protein Name | Perilipin-5Lipid Droplet-Associated Protein Pat-1Lipid Storage Droplet Protein 5Myocardial Ld Protein |
| Database Links | |
| Cellular Localisation | Lipid DropletCytoplasmMitochondrionLipid Droplet Surface-AssociatedExchanges Between Lipid Droplets And The Cytoplasm |
| Alternative Antibody Names | Anti-Perilipin-5 antibodyAnti-Lipid Droplet-Associated Protein Pat-1 antibodyAnti-Lipid Storage Droplet Protein 5 antibodyAnti-Myocardial Ld Protein antibodyAnti-Plin5 antibodyAnti-Lsdp5 antibodyAnti-Mldp antibodyAnti-Oxpat antibodyAnti-Pat1 antibody |
Information sourced from Uniprot.org