| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Perilipin-1 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLIN1 |
| Gene ID: | 5346 |
| Uniprot ID: | PLIN1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Perilipin-1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human Perilipin-1 |
| Post Translational Modifications | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet. |
| Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| Protein Name | Perilipin-1 Lipid Droplet-Associated Protein |
| Database Links | Reactome: R-HSA-163560 Reactome: R-HSA-381340 Reactome: R-HSA-9031528 |
| Cellular Localisation | Endoplasmic Reticulum Lipid Droplet Lipid Droplet Surface-Associated |
| Alternative Antibody Names | Anti-Perilipin-1 antibody Anti-Lipid Droplet-Associated Protein antibody Anti-PLIN1 antibody Anti-PERI antibody Anti-PLIN antibody |
Information sourced from Uniprot.org
