Anti-PLGF antibody [R08-9C2] (STJA0033874)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human PLGF
General Information
| Short Description | Rabbit monoclonal anti-PLGF for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-9C2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PGF |
| Gene ID | 5228 |
| Uniprot ID | PLGF_HUMAN |
| Immunogen | A synthetic peptide of human PLGF |
Additional Info
| Tissue Specificity | While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. |
| Post Translational Modifications | N-glycosylated. |
| Function | Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. |
| Protein Name | Placenta Growth FactorPlgf |
| Database Links | Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | SecretedThe Three Isoforms Are Secreted But Plgf-2 Appears To Remain Cell Attached Unless Released By Heparin |
| Alternative Antibody Names | Anti-Placenta Growth Factor antibodyAnti-Plgf antibodyAnti-PGF antibodyAnti-PGFL antibodyAnti-PLGF antibody |
Information sourced from Uniprot.org