| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-5 3 exonuclease PLD4 (457-506 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLD4 |
| Gene ID: |
122618 |
| Uniprot ID: |
PLD4_HUMAN |
| Immunogen Region: |
457-506 aa |
| Specificity: |
PC-PLD4 Polyclonal Antibody detects endogenous levels of PC-PLD4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human PLD4 at the amino acid range 457-506 |
| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. |
| Protein Name | 5'-3' Exonuclease Pld4Choline Phosphatase 4Phosphatidylcholine-Hydrolyzing Phospholipase D4Phospholipase D Family Member 4Phospholipase D4Pld 4 |
| Database Links | Reactome: R-HSA-1483148Reactome: R-HSA-1855204Reactome: R-HSA-2029485 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneNucleusEarly EndosomeCytoplasmic VesiclePhagosomeActivation Of Microglia Induces Translocation Of Pld4 From The Nucleus To The Phagosomes |
| Alternative Antibody Names | Anti-5'-3' Exonuclease Pld4 antibodyAnti-Choline Phosphatase 4 antibodyAnti-Phosphatidylcholine-Hydrolyzing Phospholipase D4 antibodyAnti-Phospholipase D Family Member 4 antibodyAnti-Phospholipase D4 antibodyAnti-Pld 4 antibodyAnti-PLD4 antibodyAnti-C14orf175 antibodyAnti-UNQ2488 antibodyAnti-PRO5775 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
